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First-Line Nivolumab Plus Ipilimumab in Advanced Non-Small Cell Lung Cancer: 4-Year Outcomes From the Randomized, Open-Label, Phase 3 CheckMate 227 Part 1 Trial

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This, in turn, can support the validation of candidate biomarkers as clinical endpoints in future trials, ultimately strengthening the translational value of short-term human studies, where direct health outcomes may be difficult to capture but biomarker improvements can serve as early indicators of potential health benefits