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Early-stage organoids (Day 7) exhibited a proteomic profile characteristic of hepatoblast-like populations, marked by high levels of stem cell-associated transcription factors such as hepatocyte nuclear factor 1 alpha (HNF1A), hepatocyte nuclear factor 4 alpha (HNF4A), and forkhead box protein A2 (FOXA2) (Fig

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Perhaps reflecting the effect of ethanol on respirations as well as the muscle-relaxant effects of this drug, heavier drinking can be associated with sleep apnea, especially in older alcohol-dependent subjects