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A recent study has shown that it is now feasible to standardize all PTH assays by recalibrating PTH immunoassays using liquid chromatography coupled with mass spectrometry as the reference method, regardless of the assay methodology (second or third generation immunoassay) (260)

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Furthermore, the results reported that most of the hydrophobic face of the PNC-27 peptide, is composed of residues 6-15 in the HDM-2-binding domain