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Three members of the TGFβ family (TGFβ1, 2, 3) promote LOX and LOXL1-4 expression in human trabecular meshwork (sponge-like connective tissue located in the proximal side of the eye) cells via both Smad and non-Smad pathways (MAPK/JNK and AP-1) through TGFβR1 and TGFβR2 (Sethi et al ., 2011)
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