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The one significant finding came from a patient questionnaire: self-reported improvement in overall skin quality favoured the GHK-Cu group (P = 0.04).[6] Other frequently quoted claims include increased skin thickness, improved elasticity and reduced wrinkles are largely derived from older cosmetic studies and company-linked research

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MicroRNA 146a is believed to interact with intracellular mediators such as interleukin 1 receptor-associated kinase 1 and mammal-affiliated tumor necrosis factor receptor-associated factor 6, both of which are involved in cytokine-related signal transduction