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Already after the first seconds from the oxidizing event, the glycolysis regulatory enzymes (GAPDH and pyruvate kinase) are inactivated, thus causing glycolysis blockage and glucose diversion to the PPP flow [70,71]

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Enucleated RBCs lack transcriptomes but contain long DNA fragments of both nuclear and mitochondrial origin, some retained transcripts, or microRNA molecules, and can acquire exogenous nucleic acids [196, 197]