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However, while in red cells, the reaction catalyzed by G6PD is the only source of NADPH, in mitochondria-containing cells, the coenzyme can originate from at least three additional pathways: Malic enzyme (ME1, EC.1.1.1.40) [122] NADP + -dependent isocitrate dehydrogenase (IDH2, EC 1.1.1.42) [122] Nicotinamide nucleotide transhydrogenase (NNT, EC 1.6.1.3) [123] In adipose and liver cells, IDH2 is the major source of NADPH [124]

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Ageing is believed to be a condition associated with free radical production (Busciglio & Yanker, 1995