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These defects may reduce the capacity of newly generated or remodeled mitochondria to establish membrane potential, diminish oxidative phosphorylation efficiency, and weaken antioxidant stress resistance, thereby exacerbating aging-associated declines in energy metabolism ( 3.2 Spatial organization and network topology shape the platform for mitochondrial quality control Beyond molecular composition, the subcellular spatial distribution and network topology of mitochondria profoundly influence their functional performance and MQC efficiency ( In most eukaryotic cells, mitochondria form dynamically interconnected networks through fusion and fission
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The results of the analysis were listed in Supplementary Data Files 1, 2, 3, and 4
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