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Ruenzi 2005 was a multicentre randomised double-blind placebo-controlled Phase 2 in ulcerative colitis, 53 randomised, 80 mg/day enema for 14 days, published only as a meeting abstract

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This hypothesis was supported by results that also OPC differentiation was significantly induced, axons were re-wrapped, and axonal damage was reduced after Tβ4 treatment at the late stage of EAE (day 30 after onset), and that OPC differentiation significantly correlates with the neurological functional score (Zhang et al., 2016a)